Your safety is our first priority. Learn more about key medication details, possible side effects, warnings, and other important information about estradiol tablet below.
Prescribing Information
Estradiol tablets are systemic prescription estrogen products used for selected menopause-related and other hormone indications. Treatment should be individualized and periodically reevaluated. Patients with a uterus may need a progestogen to reduce endometrial-hyperplasia and cancer risk.
Black Box Warning
Estradiol tablets carry boxed warnings for endometrial cancer and cardiovascular and other serious risks. Unopposed estrogen increases endometrial-cancer risk in a patient with a uterus. Estrogen with or without a progestin should not be used to prevent cardiovascular disease or dementia.
Common Side Effects
Common or possible side effects may include:
- Breast tenderness
- Headache or migraine
- Nausea
- Abdominal bloating or cramps
- Spotting or abnormal bleeding
- Mood changes
- Fluid retention
- Leg cramps
- Changes in weight
- Changes in libido
Important Safety Information
Do not use estradiol tablets if you have unexplained genital bleeding, known or suspected breast or estrogen-dependent cancer, active or prior blood clots, stroke or heart attack, significant liver disease, a known clotting disorder, pregnancy, or an allergy to the product, unless your specialist determines otherwise.
Tell your provider about cancer risk, migraine, high blood pressure, diabetes, smoking, high cholesterol, obesity, lupus, gallbladder disease, asthma, seizures, endometriosis, uterine fibroids, surgery, prolonged immobilization, pregnancy, and breastfeeding.
Use the lowest effective dose for the shortest duration consistent with treatment goals. Periodic breast screening and evaluation of abnormal bleeding are important. Your provider may advise holding treatment before certain surgeries or prolonged immobilization.
Seek urgent medical help for chest pain, sudden shortness of breath, coughing blood, one-sided weakness, severe headache, sudden vision changes, leg swelling, or signs of an allergic reaction.
To report suspected adverse reactions, contact the FDA at 1-800-FDA-1088 or visit www.fda.gov/medwatch.
