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Topical Spironolactone 5%

From Current price is: $119.00. Original price was: $169.00./mo.

From Current price is: $119.00. Original price was: $169.00./mo.

A provider-guided compounded topical spironolactone option that may be considered for eligible patients with acne, oiliness, or other androgen-related skin concerns. The topical formulation is not FDA-approved as a finished drug product and should be used with ingredient-specific pregnancy and medication precautions.

A provider-guided compounded topical spironolactone option that may be considered for eligible patients with acne, oiliness, or other androgen-related skin concerns. The topical formulation is not FDA-approved as a finished drug product and should be used with ingredient-specific pregnancy and medication precautions.

  • A compounded topical anti-androgen treatment option
  • May be considered for selected acne or androgen-related skin concerns
  • Designed for localized application according to provider instructions
  • Requires review of pregnancy status, kidney health, potassium risk, and other medications

  • Contains spironolactone in a 5% topical formulation
  • Topical spironolactone is not FDA-approved as a finished drug product
  • Local absorption and systemic exposure may vary by formula, dose, and application area
  • Oral spironolactone safety information may still be relevant if meaningful systemic absorption occurs

  • Apply only as prescribed by your licensed provider
  • Use the amount, frequency, and application area listed on the pharmacy label
  • Wash hands after use and avoid the eyes, mouth, broken skin, and unintended transfer
  • Contact your care team for severe irritation, weakness, fainting, irregular heartbeat, or other concerns

Less guesswork, more results

  • Applied directly to acne-prone areas
  • Targets androgen-related pathways in the skin
  • Studied for reducing acne breakouts
  • Localized treatment without taking oral spironolactone
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How Topical Spironolactone 5% works in the body

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Targets hormone-driven skin pathways

Spironolactone has anti-androgen activity. Topical formulations aim to bring that activity directly to areas of the skin affected by androgen-related breakouts.

Helps address stubborn breakouts

Clinical studies of topical spironolactone have reported reductions in acne lesion counts in some patients.

Localized skincare treatment

Unlike oral spironolactone, the topical formulation is applied directly to the prescribed skin areas as part of a personalized skincare routine.

Treatment Options

No hidden fees, ever

1 Month Supply

$149/first month
$199/mo. after

All treatments include:

  • Third-party tested, high-quality formulations
  • Personalized protocols, nutrition plans & ongoing coaching
  • Free shipping & unlimited clinician messaging
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3 Month Supply

$119/first month
$169/mo. after

All treatments include:

  • Third-party tested, high-quality formulations
  • Personalized protocols, nutrition plans & ongoing coaching
  • Free shipping & unlimited clinician messaging
Get started

Expert solutions,tailored to you

Have questions?

Frequently asked questions

What is topical spironolactone?

It is a topical formulation of spironolactone used in some compounded dermatology programs for androgen-related skin concerns such as acne.

How does topical spironolactone work?

Spironolactone has anti-androgen activity, and the topical approach is intended to deliver treatment directly to the skin.

Has topical spironolactone been studied for acne?

Yes. Clinical studies, including research involving 5% topical spironolactone, have reported reductions in acne lesion counts.

Is topical spironolactone FDA-approved for acne?

No. A compounded topical spironolactone formulation is not an FDA-approved acne medication.

How do I apply it?

Follow the exact amount, frequency and application instructions provided by your clinician and dispensing pharmacy because compounded formulations can differ.

Is topical spironolactone for men and women?

Topical spironolactone has been studied in acne patients, but whether it is appropriate should be determined individually by the prescribing clinician.

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